It is conceivable that p53 activation causes at least some of the DBA phenotypes [61,74], but the potential role of p53 in DBA is somewhat confusing given the identification of mutations in RPL5 and RPL11, both of which are required for p53 stabilization in response to nucleolar stress, according to numerous in vitro studies. This evidence concerns the gene RPL11 and Diamond-Blackfan anemia.