KCNJ11 and type 2 diabetes mellitus: Figure S1 shows the literature search and selection process for eligible studies (Figure S1). Finally, a total of 48 studies including 56,349 cases, 81,800 controls and 483 family trios, were retrieved based on the search criteria for T2D susceptibility related to the KCNJ11 E23K polymorphism [15]–[62]. In addition, almost all studies indicated that the distribution of genotype frequencies among the control groups were consistent with HWE. The detailed characteristics of all the included studies of this meta-analysis were summarized in Table 1.