Highly expressed receptor for advanced glycation end products (RAGE), as an inflammatory receptor, contributes to the activation of interleukin 6 (IL-6)-mediated mitochondrial pathway and transcription 3 (STAT3) signaling, which activates autophagy, inhibits apoptosis, thereby promoting cell survival in pancreatic cancer in vivo and in vitro [67,68]. Here, IL6 is linked to pancreatic neoplasm.