MUTYH and colorectal carcinoma: This is the case for major CRC genetic syndromes, which include familial adenomatous polyposis (FAP), attenuated FAP (AFAP), hereditary non-polyposis colorectal cancer (HNPCC) or Lynch Syndrome, MUTYH (mut-Y homolog) associated polyposis and rare hamartomatous polyposis conditions such as the Peutz-Jeghers (PJ) syndrome, the juvenile polyposis (JP) syndrome, the Cowden syndrome and the Bannayan-Riley-Ruvalcaba (BRR) syndrome.