The transcriptional shift from HIF-1α- to FoxO3A-dependent gene expression promoted by p38α blockade indirectly shows that HIF-1α suppression could prove beneficial to prevent tumor growth, angiogenesis and cell adaptation to hypoxia or to energy depletion in CRC, even though its activation would be desirable in the first phases of the immune response. This evidence concerns the gene HIF1A and colorectal carcinoma.