Indeed, inhibition of mTor through rapamycin treatment or blockage of the PI3K-AKT-mTOR oncogenic pathway, which is activated in several malignancies including CRC, mimics starvation conditions and promotes autophagy; similar evidence has been obtained also in yeast, C. elegans and D. melanogaster [69,70]. The gene discussed is AKT1; the disease is colorectal carcinoma.