In an effort to elucidate the mechanisms involved, Din and coworkers showed that the protective action of aspirin against the development of CRC is due to inhibition of the mTor-signaling effectors S6K1 and 4E-BP1, changes in nucleotide ratios and activation of AMPK, which result in increased autophagy [132]. The gene discussed is MTOR; the disease is colorectal carcinoma.