A subsequent meta-analysis of three GWAS with 3230 adult CD cases and 4829 controls demonstrated that the A allele of a SNP on chromosome 12q12 (rs11564258) was over-represented in CD patients, tagging a 0.89 Mb region containing both Leucine-rich repeat serine/threonine protein kinase 2 (LRRK2) and mucin 19, oligomeric (MUC19) [41]; this was later replicated in a paediatric GWAS [54]. Here, MUC19 is linked to Cowden disease.