A change in cell death profile, apoptosis/autophagy and vice versa, following photodynamic treatment has been also demonstrated after 5-ALA photosensitizition of the U2OS osteosarcoma cell line deficient in receptor-interacting protein 3 (RIP3), a key molecule in necroptosis [137,138,139] and apoptosis [140,141]. The gene discussed is RIPK3; the disease is osteosarcoma.