VEGFA and Hepatic fibrosis: Our findings demonstrated that: 1) brivanib reduced mouse liver fibrosis induced by bile duct ligation, carbon tetrachloride, and thioacetamide; 2) brivanib decreased cell proliferation induced by treatment of human hepatic stellate cells with PDGF, VEGF and FGF; 3) brivanib abrogated PDGF-BB mediated phosphorylation of its cognate receptor.