Since the effect of brivanib on liver fibrosis has not been studied, the aim of this study was to explore the effect of brivanib on liver fibrosis in three different mouse models, as well as the effects of brivanib on TGF-β, PDGF, VEGF, and FGF-induced proliferation and activation of hepatic stellate cells. The gene discussed is VEGFA; the disease is Hepatic fibrosis.