Since the effect of brivanib on liver fibrosis has not been studied, the aim of this study was to explore the effect of brivanib on liver fibrosis in three different mouse models, as well as the effects of brivanib on TGF-β, PDGF, VEGF, and FGF-induced proliferation and activation of hepatic stellate cells. Here, TGFB1 is linked to Hepatic fibrosis.