IGF1 and Hepatic fibrosis: Growth factors elevated in liver fibrosis and cirrhosis that have been implicated in carcinogenesis include transforming growth factor alpha (TGF-α), epidermal growth factor (EGF), insulin-like growth factor 1 (IGF1), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF) [5], [6], [7], [8].