On the other hand, it was demonstrated that a female founder harboring a 12.5 kb TSPY transgene, including also a complete 2.8 kb structural TSPY gene, developed gonadoblastoma-like structures in both ovaries, which expressed the TSPY transgene in a pattern resembling the expression pattern of TSPY in human gonadoblastoma [49,53]. This evidence concerns the gene TSPY1 and gonadoblastoma.