PRMT5 protein levels are increased in CLL cell lines secondary to the altered expression of PRMT5-specific miRs 19a, 25, 32, 92, 92b, and 96 (discussed below) that results in an increase of global symmetric methylation of H3R8 and H4R3. The gene discussed is PRMT5; the disease is B-cell chronic lymphocytic leukemia.