In the future study, we should investigate whether endogenous AM could also inhibit the enhanced CSAR by binding with its receptor complex (CRLR/RAMP2 or CRLR/RAMP3) in the PVN in CHF rats and whether the effect of IMD on CSAR is associated with unidentfied receptor in the PVN. This evidence concerns the gene RAMP3 and congestive heart failure.