The primary findings in this study were that the levels of IMD and Ang II in the PVN were increased in CHF rats; IMD in the PVN significantly lowered the CSAR and the baseline RSNA and MAP in CHF rats than those in Sham rats; PVN pretreatment with IMD suppressed the enhanced CSAR and superoxide anions responses to Ang II in the PVN in Sham and CHF rats. This evidence concerns the gene AGT and congestive heart failure.