In the future study, we should investigate whether endogenous AM could also inhibit the enhanced CSAR by binding with its receptor complex (CRLR/RAMP2 or CRLR/RAMP3) in the PVN in CHF rats and whether the effect of IMD on CSAR is associated with unidentfied receptor in the PVN. Here, RAMP2 is linked to congestive heart failure.