In this study, the effect of IMD on CSAR was blocked with AM receptor antagonist AM22-52 but not CGRP receptor antagonist CGRP8-37, one possibility is that the level of RAMP1 expression remained small in CHF state and it was not enough to block the effect of IMD, the other is that IMD displayed its action on the CSAR through AM receptor not CGRP receptor. Here, RAMP1 is linked to congestive heart failure.