AGTR1 and congestive heart failure: Angiotensin II (Ang II), AT1 receptors and reactive oxygen species (ROS) in the PVN play an important role in the central modulation of CSAR, contribute to the pathogenesis of enhanced CSAR in CHF [23]–[25], and AT1 receptor mRNA antisense normalizes the enhanced CSAR in CHF rats [26].