Analysis of transcriptional profiles in a proprietary database of myeloma cell lines identified 12 significantly overexpressed genes in the KMS-26 amplified region, including TNFRSF13B/TACI, COPS3, NCOR1 and TRPV2, and the TNFRSF13B/TACI gene showed the highest average fold-change (>8); it encodes a receptor for the B-cell activating factor (BAFF) and the proliferation-inducing ligand (APRIL), which are thought to contribute to survival of MM cells. The gene discussed is TNFSF13B; the disease is Miyoshi myopathy.