In addition, induction of MMP-9 and cathepsin B expression was observed upon transfection of TRPV2 in the LNCaP cell line, and knockout of TRPV2 by siRNA reduced the growth and the invasive properties of PC3 cells by progressive down-regulation of MMP-2, MMP-9 and cathepsin B expression in a xenograft tumor model [71]. Here, MMP9 is linked to neoplasm.