IGF1 and urinary bladder neoplasm: Given the high level of IGF-1/IGF-1 receptor (IGF-1R) found in bladder tumors and its role in bladder cancer progression [66], and the strong TRPV2 increase in high-grade and -stage tumors [27], we suggest that the TRPV2/ IGF-1/IGF-1R pathway plays an important role in the control of UC growth and progression.