In addition, the TRPV2 agonist, cannabidiol (CBD), a non-psychoactive cannabinoid with anti-tumoral activity, alone, or in combination with bortezomib, strongly inhibited cell growth, arrested cell cycle progression, and induced cell death of MM cells, by regulating the ERK, AKT and NF-κB signaling pathways, with the major effects observed in the RPMI8226 and U266 MM cell lines transfected with TRPV2, compared to the untransfected RPMI8226 and U266 cell lines [24]. This evidence concerns the gene TRPV2 and Miyoshi myopathy.