TRPV2 and urinary bladder cancer: Moreover, the s-TRPV2 variant was expressed in low-grade RT4 cells, and irrespective of grade of malignancy its expression progressively decreased in pTa, pT1, and pT2 and was undetectable in high grade EJ and J82 cells, and pT3 and pT4 invasive bladder cancer tissues (Figure 2).