Finally, we also observed significant differences in the short/full TRPV2 form ratio from NB to pTa and pT1 stages, strongly suggesting that loss of s-TRPV2 may represent an early event in bladder carcinogenesis, and that the enhanced TRPV2 expression in high-staged muscle-invasive UC (pT2-T4) could be secondary to this event. This evidence concerns the gene TRPV2 and carcinoma.