TRPV2 and neoplasm: In this regard, it is plausible that TRPV2 plays a major role in the first events that parallel the transformation of a single normal stem/progenitor cell into a tumor cell; moreover, the TRPV2 expression was also modulated during the carcinogenesis process that follows a long and continuous exposure to different carcinogenetic agents, resulting in tumor growth and progression and selection of more aggressive tumor clones.