TRPV2-regulated cytosolic calcium levels promoted PC3 migration by induction of key proteases, namely matrix metalloproteinase-2 (MMP-2), MMP-9 and cathepsin B. The expression profile of some TRP channels changes during the development and the progression of prostate cancer towards hormone-refractory stages [70]. The gene discussed is TRPV2; the disease is Familial prostate cancer.