LRIG1 and neoplasm: To compare the LRIG1 expression between benign and malignant tumors, Tanemura et al. performed immunohistochemical analysis on well-differentiated and undifferentiated cutaneous SCC and found that LRIG1 expression was decreased in most tumor cells in undifferentiated (high-grade) cutaneous SCC like other tumors, and more interestingly, that it was inversely increased in most cases of well-differentiated (low-grade) cutaneous SCC [24].