Moreover, Xie et al. reported that the downregulation of LRIG1 promotes the aggressive properties of glioma cells via EGFR/Akt/c-Myc activation [37], and Mao et al. showed that LRIG1 restricts glioma aggressiveness by inhibiting cell proliferation, migration, and invasion [36]. This evidence concerns the gene AKT1 and central nervous system cancer.