LEPR and asthma: Yousefi et al. (2013) found that the LEPR genotype interacted with maternal smoking to associate with methylation of LEPR. A SNP within the IL4R gene combined with methylation at a CpG site within the same gene predicts the risk of childhood asthma (Soto-Ramirez et al. 2013). Moreover, Klengel et al. (2013) found that interaction of the FKBP5 genotype and early childhood trauma affects methylation of FKBP5 intron 7, FKBP5 expression, and subsequent deregulation of glucocorticoid receptor signaling.