Indeed, similar results from Lee et al. reported that XAF-1 hypermethylation of total or partial 14 CpG loci from -20 to -695 of the promoter, was associated to a decrease in XAF-1 expression and is correlated with disease progression, in particular malignancy in bladder cancers [122]. The gene discussed is XAF1; the disease is urinary bladder cancer.