TRPS1 and Familial prostate cancer: Proteomic analysis of androgen-independent DU145 prostate cancer cells that do not express TRPS1 and of genetically engineered DU145 cells that stably express recombinant TRPS1 have demonstrated that TRPS1 suppresses the protein expression of certain antioxidants, including superoxide dismutase, protein disulfide isomerase A3 precursor, endoplasmin precursor, and annexin A2 [51].