UBE4B and neuroblastoma: As for the other genes identified in the 1p36.2 region, no evidence has yet been presented to confirm that they are involved in apoptotic cell death in NB, although expression levels of PEX14 and UFD2a are higher in favorable NBs as compared to unfavorable ones [83,92] and a splice site mutation is detected in the UFD2 gene in a stage 3 NB with a fatal outcome [92].