Nevertheless, induction of caspase 8 by INFγ is not sufficient for most TRAIL-resistant NB cells to undergo apoptosis, while chemotherapy in combination with INFγ and TRAIL treatment dramatically restores apoptosis sensitivity even in chemo- and TRAIL- resistant NB cells by synergistic induction of both caspase 8 and TRAIL receptors [129,130]. The gene discussed is CASP8; the disease is neuroblastoma.