In addition to genomic and epigenetic mechanisms, inactivation of caspase 8 in NB may be also caused by alternative splicing of intron 8 in the CASP8 gene, which produces caspase 8L, an isoform lacking caspase activity and therefore acting as a dominant negative inhibitor of wild-type caspase 8 [126]. This evidence concerns the gene CASP8 and neuroblastoma.