CASP8 and neuroblastoma: Besides caspase 8, Fas receptor CD95 as well as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors DCR1 and DCR2 have been found to be hypermethylated in their promoter regions in NB [127,128], leading to tumor-specific downregulation of these genes and therefore impairing apoptosis signaling via death receptor pathway in NB.