FPR2 and chronic obstructive pulmonary disease: For example, another FPR2/ALX ligand, SAA generates potent anti-apoptosis signals that can be overridden by LXA4 [38], whereas excessive production of SAA was found to mediate exacerbation of glucocorticoid-refractory lung inflammation in patients with chronic obstructive pulmonary disease by overwhelming LXA4-generated anti-inflammatory signaling [107].