NR3C1 and arthritic joint disease: The non-steroidal plant-derived Compound A (CpdA) has been proposed as a dissociative ligand of GR, and studies indicate it may have less side effects and be just as beneficial as dexamethasone to anti-inflammatory therapy in murine models of asthma [121], arthritis, [122] and experimental autoimmune encephalomyelitis [123].