The oxidatively stressed syncytiotrophoblast responds by the increased release of two anti-angiogenic factors – soluble vascular endothelial growth factor receptor-1 (sVEGFR-1, also called sFlt-1) and soluble endoglin – into the maternal circulation that oppose the actions of vascular endothelial growth factor and placental growth factor (PlGF)(11–13), leading to endothelial dysfunction, hypertension and proteinuria. The gene discussed is PGF; the disease is endothelial dysfunction.