In summary, the positive and specific correlation between MYC and JAG2 for LCA tumors and highly metastatic MB stages is consistent with the Group 3-specific association between MYC and JAG2. This further strengthens the notion of a functional interaction between these two proteins and suggests that high JAG2 level may be indicative of aggressive MB tumors. Here, JAG2 is linked to Leber congenital amaurosis.