Thus, our findings suggest that while growth factor stimulation is linked to the activation of the Ras/MAPK and PI3K/Akt pathways, in part through Grb2 and Shc, Erk or Akt activity levels in CRC may not reliably predict the extent of RTK deregulation, nor the sensitivity to therapies targeting them. Here, AKT1 is linked to colorectal carcinoma.