MAPK8 and acute myeloid leukemia: We found overexpression of miR-155 led to increase in cJUN, FOS and TRIB2, and decrease in MEIS1, GFI1, cMYC and JARID2. Induction of AP-1 transcription factors have been reported to result in increased phosphorylation activity of JNK and activation of caspase-3 dependent apoptosis in AML [46,47].