Moreover, our data indicate disruption and relocation of VE-cadherin with a concomitant increase in the soluble VCAM-1 expression, by hypo and hyperglycemia in hCMEC/D3 cells, effects that are critical to progression of BBB inflammation and augmented leukocyte infiltration in diabetes [31,59,66,67]. This evidence concerns the gene CDH5 and Hyperglycemia.