IL6 and Hypoglycemia: Further, as shown in Figure 5B, hypoglycemia significantly decreased the release of interleukin-6 (IL-6, a pro-inflammatory cytokine that holds a key role in the inflammatory signaling at BBB [31]), from hCMEC/D3 monolayers at 3 h (~4-fold decrease, p < 0.01, vs. control) and 24 h (~10-fold decrease, p < 0.01, vs. control).