Similar effects on VE-cadherin distribution (disruption of VE-cadherin at cell-cell contacts) was observed under hyperglycemic condition, although in contrast to hypoglycemia, hyperglycemia significantly increased total VE-cadherin expression, as demonstrated by western blots (p < 0.05, vs. control, Figure 6A) at 3 h. The gene discussed is CDH5; the disease is Hyperglycemia.