PROS1 and diabetes mellitus: Alternatively, in rodent models, experimental diabetes changed the phosphorylation of the sarcomeric protein troponin I[44,45] and also markedly shifted the myosin heavy chain (MHC) from the fast (V1) to the slow (V3) isoform[46,47], although the later might be less important in humans as most MHC already is predominantly in the slow isoform[48].