Under physiological conditions, MIF is produced by pancreatic β cells and can maintain its insulin secretion activity[22-27], but scholars became interested in its role in kinds of glucose metabolic disorder in recent years, including T1DM, T2DM, gestational diabetes mellitus (GDM), and obesity induced insulin resistance (IR)[16,28,29]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.