Also consistent is that protein levels of the mTOR pathway suppressors, PTEN and INPP4B, are relatively low in BLBC or TNBC patient tumors compared with other breast cancer subtypes [14,32,34,36]; and mTOR pathway-related proteins, especially AKT and 4EBP1, show high phosphorylation levels in BLBCs [33,34]. This evidence concerns the gene PTEN and breast cancer.