For all primary tumor xenografts, the overall phosphorylation of mTOR, S6K1, 4EBP1 and eIF4E proteins was decreased by 53%, 33%, 62% and 64%, respectively, in rapamycin-treated tumors compared with tumors in the pretreatment and control groups (Table S5 in Additional file 7), supporting decreased mTOR pathway activity after treatment. This evidence concerns the gene MTOR and neoplasm.