HMOX1 and myocardial infarction: To the best of our knowledge the only documentation of the beneficial effect of post-MI HO-1 over-expression comes from Lin and coworkers [19] who showed that invasive injection of recombinant AAV bearing HO-1 gene into the border-zone early after induction of MI in mice, promoted neovascularization in the ischemic region and significantly limited left ventricular (LV) fibrosis and dysfunction at 4 weeks.