Given that both of c-Abl tyrosine kinase inhibitors and endothelin receptor antagonists target Fli1, a potential predisposing factor of SSc, further studies on the association between the degree of Fli1 suppression and the clinical efficacy of these drugs may provide us some clue to properly select good responders and effectively administer these treatments for SSc patients. The gene discussed is FLI1; the disease is systemic sclerosis.