Several studies have shown that NO can upregulate Ang-1 expression after stroke, and the effects of inflammatory cytokines on the expression of Ang-1 and Ang-2 depend on their concentration: high concentrations of cytokines result in negative expression of Ang-1 and Ang-2, while low concentrations of cytokines result in positive expression of Ang-1 and Ang-2 [30-33]. The gene discussed is ANGPT1; the disease is stroke disorder.