In HBV-infected women, after controlling for age, CD4+ count above or below 250/mm3 and hemoglobin level, a baseline HBV-DNA level > 10,000 IU/ml was significantly associated with the development of liver toxicity of any grade (HR:3.278, 95% CI 1.056-10.180, P = 0.040). Here, CD4 is linked to toxicity.