They have shown that calories supplementation which contained one quarter piece of fresh fruit, i.e. 25 kcal that was equal to 138–181% of calorie intake, during amenorrhea induced by strenuous exercise, caused increases in reproductive hormone levels, i.e. FSH and LH, and reestablished ovulatory cycles in female cynomolgus monkeys. The gene discussed is PLOD1; the disease is amenorrhea.