Many recent studies have also demonstrated that the expression of circadian clock genes is disturbed in cancers such as hepatocellular carcinoma (HCC) [18], chronic myeloid leukemia (CML) [19,20], and head and neck squamous cell carcinoma (HNSCC) [21]. The gene discussed is CLOCK; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.