The next step in translating these findings into biomedicallyuseful information is to find out the mechanism of the action of these genes.However, GWAS studies often implicate genes whose functions are currently unknown;for example, MYEOV, ANKLE1, TMEM45B and ORAOV1 are found to be associated withbreast cancer, but their molecular function is unknown. This evidence concerns the gene TMEM45B and cancer.