Mouse models provide specific evidence for the interaction of HOXC6 with multiple downstream targets including bone morphogenic protein 7 (BMP7), fibroblast growth factor receptor 2 (FGFR2), and platelet-derived growth factor receptor α (PDGFRA) that promote PCa metastasis to the bone microenvironment [42]. Here, HOXC6 is linked to posterior cortical atrophy.