G6PD and hyperinsulinemic hypoglycemia, familial, 4: Others are dose-dependent and correlated with PK factors, such as the total AUC and the maximum concentration reached (cmax), e g, the length of the corrected interval between the Q and T wave in the heart’s electrical cycle is positively correlated with halofantrine exposure [55], glucose-6-phosphate dehydrogenase (G6PD) deficiency mediates dose-related toxicity in primaquine [56] and pruritus in sensitive individuals is linked to chloroquine levels [57].