To investigate whether DNP-mediated LYRIC is involved in NPC metastasis, we first detected phospho-LYRIC expression in NPC tissues, and found that phospho-LYRIC Ser 568 is highly expressed in NPC tissues, which was expressed at higher levels in metastatic tissues than in primary site tissues (Additional file3: Figure S1). The gene discussed is MTDH; the disease is nasopharyngeal carcinoma.