FLT4 and neoplasm: Given the role of the VEGF-C/VEGFR-3 signaling in tumor lymphangiogenesis andmetastasis, inhibiting this pathway with soluble VEGFR-3, neutralizing antibodies toVEGFR-3 or VEGF-C, or suppressing VEGF-C expression with siRNAs can reduce lymphnode and organ metastasis in rodent models [29-32].