By modulating the cytoskeleton, Slit2 has been shown to enhance vascularstability [52,79], inhibit HIV-induced migration of dendritic cells [77], inhibit the infection of CD4+ T-cells by HIV-1 [81], block cell-to-cell transmission of HIV-1 (our unpublished data), andinhibit PDGF-induced migration of smooth muscle cells [78]. Here, CD4 is linked to infection.