EWSR1 and neoplasm: The presence of tumor-specific transcripts in vesicles, moreover, is not limited to PCa but it is also present in other cancers suggesting that tumor-specific transcripts contained in vesicles could serve for diagnostic of cancer diseases; in Ewing's sarcoma (ES), for example, it has been found that both exosomes and microvesicles contained the ES specific transcript EWS-FLI1, which is not present in healthy donors and might be useful as a noninvasive diagnostic ES marker in peripheral blood [121, 122].