Lung cancer is a complex, multifactorial disease which is the leading cause of cancer death in both men and women.NF-κB is a transcription factor which is known to affect the expression of more than 150 genes related to inflammation, lymphocyte activation, cell proliferation, differentiation, and apoptosis, as well as contributing to cell apoptosis and survival. The gene discussed is NFKB1; the disease is lung cancer.