A significant correlation between genotype combinations of NF-κB1 and NF-κBIA (DDAG genotype) and NSCLC risk was found compared to all other combinations (P: 0.025; O.R: 5.035; 95% CI: 1.067–24.14) and DDAG genotype had increased risk for NSCLC. This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.