IL-6 is another multifunctional B-cell differentiation cytokine, which also plays important role in inducing the final maturation of activated B cells into immunoglobulin-secreting plasma cells and influencing the susceptibility of RA [7, 8, 11, 22–24], dermatomyositis and systemic lupus erythematosus [39], liver cirrhosis and hepatocellular carcinoma [40], diabetic microvascular complications [41], coronary heart disease [42], acute appendicitis [43], and so on. This evidence concerns the gene IL6 and appendicitis.