ERBB2 and breast carcinoma: Lapatinib (Tykerb, GW-572016), a dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) and HER2 receptors, has been used for advanced HER2-positive breast cancer patients who failed to chemotherapy or HER2-targeted therapy with monoclonal antibody trastuzumab [6, 7].