Only the studies using IHC showed a significant association between the expression of TUBB3 and the ORR in patients with NSCLC (OR = 0.22, 95% CI = 0.14–0.34, p<0.001; I2 = 39.4%, P = 0.06 for heterogeneity, Table 2). The gene discussed is TUBB3; the disease is non-small cell lung carcinoma.