In another study of 50 ANA positive patients that did not fulfill sufficient criteria for classification of SLE, anti-Ro60/SS-A and anti- La/SS-B antibodies were the most common detectable anti-ENA antibodies (6%) using a limited diagnostic profile and while none of the patients with leukopenia, thrombocytopenia, fatigue and arthralgia did not evolve to a full diagnosis of SLE, the authors concluded that ANA positivity connoted a form of systemic autoimmunity [40]. The gene discussed is BTG3; the disease is systemic lupus erythematosus.