Aberrant expression of RAGE or RAGE ligands in human patients with malignancies has been reported in e.g. pancreatic cancer [29], clear cell renal cell carcinoma [30], colorectal cancer [31], glioblastomas [32], primary nasopharyngeal carcinomas and their metastases to lymph nodes [33], cervical squamous cell carcinoma [34], gastric adenocarcinoma [35], and non-small cell lung cancer [36]. This evidence concerns the gene AGER and familial pancreatic carcinoma.