In patients without MG the serum concentration of RAGE in TETs was significantly lower compared to volunteers (sRAGE [pg/ml] 224.5±37.3 vs. 364.8±28.6; p = 0.003) and the HMGB1 concentrations were significantly higher (HMGB1 [ng/ml] 2.0±0.4 vs. 1.1±0.2; p = 0.025). This evidence concerns the gene HMGB1 and myasthenia gravis.