HMGB1 and myasthenia gravis: The lack of difference of sRAGE, esRAGE serum concentrations between MG+ and MG− patients with TETs may be due to different pathophysiology of thymomatous and non-thymomatous MG [61], [62].Our decision to investigate the role of RAGE and one of its ligands, HMGB1, was fueled by the lack of information about these two molecules in human thymus and thymic disease in the peer-reviewed published literature.