AGER and autoimmune disease: The recent findings showing that sRAGE and esRAGE were reduced in patients with MG, in particular the observation that sRAGE was not influenced by pharmacological, including current immunosuppressive treatments for this autoimmune disease [9]; as well as the differentiated expression in cells and areas of thymus, in particular in GC cells in FTH in MG patients, let us hypothesize a role for the intrathymic cell surface bound receptor RAGE in the “intrathymic pathogenesis of MG” [60] and possibly a mechanism for the beneficial effects of thymectomy.