SERPINE1 and ventricular fibrillation: Acute and excessive ingestion of alcohol has been demonstrated to induce QTc prolongation associated with ventricular tachyarrhythmias and sudden cardiac death in healthy adults.19 Binge drinking appears to lower the threshold of ventricular fibrillation, predisposing myocardial infarction survivors to an increased risk of sudden cardiac death.20 Binge drinking has also been demonstrated to enhance thrombosis and inhibit fibrinolysis by increasing platelet reactivity, thromboxane B2 formation, and plasminogen activator inhibitor-1 activity.