Experimental evidence of this phenomenon has been observed, for example, in NOD mice exhibiting periodic waves in the number of effector T-cells before disease onset [37], [38] and in T1D patients that received islet transplants exhibiting fluctuations in the percentage of GAD tetramer-positive T-cells in the CD4+ T-cell population from the time of hyperglycemia recurrence [39]. The gene discussed is CD4; the disease is type 1 diabetes mellitus.