G6PC2 and Hyperglycemia: In fact, it has been shown in recent work [37] that during the development of T1D in female NOD mice, NRP-V7 (a mimotope of IGRP(206–214)) specific T-cell population exhibits these distinct cycles approximately between 9 and 16 weeks of age prior to the onset of abnormally high level of blood sugar (hyperglycemia).