CD8A and type 1 diabetes mellitus: For this purpose, we develop here a dynamic model of T1D: first by including one clone of pathogenic (CD8+ and/or CD4+) T-cells in combination with B lymphocytes to analyze the interaction between a broad spectrum of autoreactive T-cell avidity and autoantigen-specific autoantibodies in predicting the time interval of T1D disease onset; second by extending the model to incorporate two clones of T-cells, each of which is reactive a given autoantigen and comprised of high and low avidity subclones, together with islet specific autoreactive B-cells and autoantibody-secreting plasma-cells.