CD4 and negative regulation of immune response: Univariate analysis was conducted for HIV-exposed infant group, taking various measures of HIV severity into account, and in particular CD4 lymphocyte count and ART status of HIV-infected mothers; no relation between ART started before or during pregnancy and SGAG was found; however, despite the small sample size (n = 845) in this multivariate analysis, severe immunosuppression in HIV-infected pregnant women (CD4 count <200 cells/mm3) was associated with SGAG (aOR: 2.5; IC: 1.3−4.8).