TLR4 and colorectal carcinoma: Our findings suggested that genetic polymorphisms in TLR-4 genes were associated with an increased risk of CRC among Asian populations (allele model: OR  = 1.50, 95%CI  = 1.19∼1.88, P = 0.001; dominant model: OR  = 1.49, 95%CI  = 1.16∼1.92, P = 0.002; respectively), but not among Caucasian or African populations (all P>0.05) (Figure 4).