Our meta-analysis results revealed that the TLR-4 399 C>T polymorphism might increase the risk of CRC (allele model: OR  = 1.77, 95%CI: 1.32∼2.36, P<0.001; dominant model: OR  = 1.83, 95%CI: 1.32∼2.52, P<0.001; respectively) (Figure 3). This evidence concerns the gene TLR4 and colorectal carcinoma.