Additionally, it is also worth noting that numerous studies have been conducted to investigate the potential associations between common polymorphisms in the TLR-4 gene and CRC risk, especially focusing on two SNPs, (299 A>G, rs4986790 and 399 C>T, rs4986791), which are located in the extracellular domain of TLR-4 [8], [10], [17]. Here, TLR4 is linked to colorectal carcinoma.