TLR4 and colorectal carcinoma: We also found that TLR-4 genetic polymorphisms were closely linked to CRC risk in the PCR-RFLP subgroup (allele model: OR  = 1.44, 95%CI  = 1.16∼1.78, P = 0.001; dominant model: OR  = 1.44, 95%CI  = 1.14∼1.82, P = 0.002; respectively) and the large sample-size subgroup (allele model: OR  = 1.48, 95%CI  = 1.19∼1.86, P = 0.001; dominant model: OR  = 1.43, 95%CI  = 1.10∼1.87, P = 0.008; respectively), but no similar correlations were observed in non-PCR-RFLP or small sample-size subgroups (all P>0.05).