TLR4 and colorectal carcinoma: Since TLR-4 is critical in immune and inflammation responses to various bacteria in the intestine [12], single nucleotide polymorphisms (SNPs) in TLR-4 may decrease the response to bacterial components, impact gut homeostasis, result in the impairment of TLRs activation, and thereby be conducive to the development of several inflammatory diseases including CRC [13], [14].