Since L265P mutation of MYD88 gene was prevalent in IgM-secreting Waldenström macroglobulinemia [24], and it was reported in up to 29% of DLBCL with an ABC-type [34], we expected to find this mutation in the IgM-secreting DLBCL subset. The gene discussed is CD40LG; the disease is Waldenstrom macroglobulinemia.