Regards to the role of excessive androgens in the natural progression from NGT to diabetes in women with PCOS, our findings are confirmatory of the association between A4, free testosterone and SHBG with enhanced insulin resistance [32], but they also suggest that hyperandrogenemia may affect also insulin secretion as FAI and concentration of SHBG were correlated with insulin secretion (Table 2). This evidence concerns the gene SHBG and diabetes mellitus.